Selçuk Üniversitesi Meram Tıp Fakültesi Nöroloji ve Fizyoloji AD, Konya

Objective: To investigate whether there was a difference between the patients with Multiple sclerosis (MS) with prolonged visual evoked potential (VEP) P100 latency and the patients with MS with normal VEP P100 latency. Methods: Twenty-five MS patients (16 female, 9 male) admitted to the clinic, because of the acute attack were included in the study. The blood was collected from the patients at 03.30 am and 10.00 am for determining melatonin level. Serum melatonin level, lipid profile and VEP P100 latency were determined. Results: There was no difference in both nocturnal and morning melatonin level and inhibition rate in melatonin level between the 8 patients in whom VEP P 100 latency was lower than 110 ms and 17 and 11 patients in whom VEP P100 latency was higher than 110 and 120 ms, respectively. Also there was no correlation between blood lipid profile and melatonin level. Conclusion: In MS patients in whom VEP P100 latency was higher, nocturnal-morning melatonin inhibition rate was somewhat lower than those in MS patients in whom VEP P100 latency was normal. The low amount of patients may be a reason for this situation. There was no correlation between blood lipid profile and melatonin level on the contrary to the literature.